Acanthamoeba differentiation: a two-faced drama of Dr Jekyll and Mr Hyde.
نویسندگان
چکیده
The ability of cyst-forming protists such as Acanthamoeba to escape death by transforming into a cyst form, that is resistant to harsh physiological, environmental and pharmacological conditions, has continued to pose a serious challenge to human and animal health. A complete understanding of the fundamental principles of genome evolution and biochemical pathways of cellular differentiation offers unprecedented opportunities to counter detrimental outcomes. Acanthamoeba can elude inhospitable conditions by forming cysts. Here we unravel the processes involved in the phenotypic switching of Acanthamoeba, which are critical in our efforts to find potential targets for chemotherapy.
منابع مشابه
Dr. Jekyll or Mr. Hyde: Information Security in the Ecosystem of Healthcare
“Jekyll and Hyde” embodies how information security affects today’s healthcare ecosystem. When security works, it promotes patient health and a smooth operating ecosystem (Dr. Jekyll); when it doesn’t, privacy and health compromises can occur (Mr. Hyde). In this paper, we argue that unusable security triggers this split personality and in doing so, compromises the heart of the healthcare ecosys...
متن کاملLublin Studies in Modern Languages and Literature
The paper engages with Stevenson’s novel The Strange Case of Dr Jekyll and Mr Hyde from the perspective of essential duality embedded in every one’s nature: it explicates the entangling nature of binaries and the aesthetics of non-disjunction of the binary self/Other as embodied in the figures of Dr Jekyll and Mr Hyde respectively. By the novel’s end, the two aspects, the Jekyllean and the Hyde...
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ورودعنوان ژورنال:
- Parasitology
دوره 139 7 شماره
صفحات -
تاریخ انتشار 2012